The Homeobox Gene MEIS1 Is Methylated in BRAFp.V600E Mutated Colon Tumors
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منابع مشابه
The Homeobox Gene MEIS1 Is Methylated in BRAFp.V600E Mutated Colon Tumors
Development of colorectal cancer (CRC) can occur both via gene mutations in tumor suppressor genes and oncogenes, as well as via epigenetic changes, including DNA methylation. Site-specific methylation in CRC regulates expression of tumor-associated genes. Right-sided colon tumors more frequently have BRAF (p.V600E) mutations and have higher methylation grades when compared to left-sided malign...
متن کاملevaluation of the methylation status of the meis1 promoter gene in colorectal cancer
background: colorectal cancer, the third most common type of cancer is a major cause of mortality worldwide. if colorectal cancer is detected at the early stages, the 5-year survival rate is 90%. meis1 homeobox gene is implicated in numerous solid tumors and hematological malignancies. therefore, the present study aims to investigate the methylation status of the meis1 gene in colorectal cancer...
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T he mammalian heart has a limited capacity for regeneration after damage. In contrast, teleost fish and urodelian amphibians readily regenerate even large cardiac defects. One of the central differences between species capable and incapable of efficient heart regenera-tion is the ability to reinitiate cardiomyocyte proliferation. The importance of cardiomyocyte proliferation for heart regenera...
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Leukemia results from the accumulation of multiple genetic alterations that disrupt the control mechanisms of normal growth and differentiation. The use of inbred mouse strains that develop leukemia has greatly facilitated the identification of genes that contribute to the neoplastic transformation of hematopoietic cells. BXH-2 mice develop myeloid leukemia as a result of the expression of an e...
متن کاملThe ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500).
Foramina parietalia permagna (FPP) (OMIM 168500) is caused by ossification defects in the parietal bones. Recently, it was shown that loss of function mutations in the MSX2 homeobox gene on chromosome 5 are responsible for the presence of these lesions in some FPP patients. However, the absence of MSX2 mutations in some of the FPP patients analysed and the presence of FPP associated with chromo...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0079898